There will always be people extolling the virtues of eating less and moving more for weight loss. The 5 Best Supplements To Burn Neck Fat. But while this may work for overweight people or the newly obese, it’s woefully inadequate for most people who’ve carried excess weight for decades.
While prevention is undoubtedly the best cure for obesity, better treatments – including anti-obesity drugs – are desperately needed for the 671 million people worldwide who are already obese.
Weight loss through dietary modification, exercise, or diet and exercise combined, results in powerful adaptive responses that leave people feeling significantly hungrier, as well as with reduced energy expenditure (the number of kilojoules the body burns through processes such as heart muscle contraction, keeping warm and physical activities).
This “famine reaction” is part of the reason for the weight regain that so many people experience after weight-loss programs.
Drugs that either reduce appetite or increase energy expenditure – or both – could help people overcome this reaction, increasing their chances of keeping the weight off after weight-loss interventions.
A glimmer of hope
But medications for weight loss have a frightfully chequered past. Almost all the pharmaceutical products that broke through to the market place are no longer legally available anywhere in the world due to safety concerns.
These drugs often act on the brain to affect appetite and energy expenditure. 2022’s Best Supplements To Burn Upper Abdomen Fat. And because the brain controls so many vital functions, including the heart, digestive and reproductive functions as well as emotions, the drugs often have undesirable side-effects such as increasing cardiovascular events or elevating the risk of suicide.
In Australia, only two of five drugs still have approval from the Therapeutic Goods Administration for use as weight-loss agents (phentermine, which is sold as Duromine, and orlistat, which is sold as Xenical). In the United States, topiramate (an anticonvulsant medication sold as Topamax) is also legally available when used in low doses, in combination with phentermine.
While these drugs offer some help to people who have been obese and are struggling to keep weight off, they’re not the perfect solution. All have side effects, and phentermine is only effective for around 12 weeks, after which the body develops tolerance.
But two papers published recently in the journal Cell offer hope. Scientists have discovered a pathway that could lead to new medications to help people to lose excess weight and keep it off.
The work is especially promising because pharmaceutical agents based on manipulating the newly-discovered pathway wouldn’t need to reach the central nervous system to be effective. What Are The Top 2 Safe Fat Burning Supplements For Women. It’s the impact of past weight-loss drugs on the central nervous system that have led to unaccepted side-effects.